Ying Ge, PhD – University of Wisconsin–Madison

Vilas Distinguished Achievement Professor | Department of Cell and Regenerative Biology, Department of Chemistry, and Human Proteomics Program

Top-down Proteomics: Bridging the Silos between Chemistry, Biology and Medicine

Friday at 7:15 PM – Fayetteville Town Center

Dr. Ge’s research is highly interdisciplinary, transcending traditional boundaries in chemistry, biology, and medicine. Her group specializes in top-down mass spectrometry-based proteomics, a powerful technology for comprehensively characterizing proteoforms resulting from genetic variations, alternative splicing, and post-translational modifications. Their work aims to understand cardiac biology and translate bench discoveries into precision medicine applications. Addressing challenges in top-down proteomics, her lab has designed and synthesized new cleavable surfactants for protein solubilization, innovative materials and strategies for multi-dimensional chromatography separation of proteins, as well as novel nanomaterials for enriching low-abundance proteins. In this seminar, Dr. Ge will discuss the recent technology development and biomedical applications of top-down proteomics in bridging disciplinary divides, offering a comprehensive understanding of the proteome and fostering collaboration across diverse scientific fields.